Dog10K An international sequencing effort to advance studies of canine domestication, phenotypes and health

Autor: Ostrander, E.A., Wang, G.-D., Larson, G., Vonholdt, B.M., Davis, B.W., Jagannathan, V., Hitte, C., Wayne, R.K., Zhang, Y.-p., André, C., Axelsson, E., Boyko, A., Forman, O., Frantz, L., Karlsson, E., Kidd, J., Leeb, T., Lindblad-Toh, K., Lohi, H., Lohmueller, K.E., Marques-Bonet, T., Mellersh, C., Savolainen, P., Schnabel, R., Yang, Z., Zhai, W.
Přispěvatelé: National Human Genome Research Institute (NHGRI), Chinese Academy of Sciences [Beijing] (CAS), University of Oxford [Oxford], Princeton University, Texas A&M University [College Station], Universität Bern [Bern], Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of California [Los Angeles] (UCLA), University of California, Uppsala University, Cornell University College of Veterinary Medicine, State University of New York (SUNY), University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Helsinki, Institució Catalana de Recerca i Estudis Avançats (ICREA), Animal Health Trust (AHT), University College of London [London] (UCL), Key Laboratory of Zoological Systematics and Evolution, Chinese Academy of Agricultural Sciences (CAAS), Princeton University, PrincetonNational Institutes of Health, NIHChinese Academy of Sciences, CAS 4PalaeogenomicsUniversity of OxfordPrinceton University, PrincetonTexas A and M University, TAMUUniversity of California, Los Angeles, UCLAUniversität Bern, Ub 8IGDRMerck Genome Research InstituteCollege of Natural Resources and Sciences, Humboldt State University, CNRSPrinceton University, PrincetonKungliga Tekniska Högskolan, KTHChinese Academy of Sciences, CASNational Institutes of Health, NIHUniversity of OxfordPrinceton University, PrincetonUniversität Bern, UbHelsingin YliopistoMorris Animal Foundation, MAFVetenskapsrådet, VRYouth Innovation Promotion Association, YIPA152453KYSB20150002National Council for Eurasian and East European Research, NCEEER ERC-2013-StG-337574-UNDEADChinese Academy of Sciences, CAS XDB13000000National Human Genome Research Institute, NHGRINE/K005243/1, ANR-11-INBS-0003, NE/K003259/1National Natural Science Foundation of China, NSFC 31621062, 91731304, ANR-11-INBS-0003,CRB-Anim,Réseau de Centres de Ressources Biologiques pour les animaux domestiques(2011), Biosciences, Veterinary Biosciences, Hannes Tapani Lohi / Principal Investigator, Helsinki One Health (HOH), Doctoral Programme in Clinical Veterinary Medicine, Doctoral Programme in Integrative Life Science, Haartman Institute (-2014), Veterinary Genetics, University of Oxford, Universität Bern [Bern] (UNIBE), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California (UC), College of Veterinary Medicine [Cornell University], Cornell University [New York]-State University of New York (SUNY), Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: National Science Review
National Science Review, Oxford Academic, 2019, 6 (4), pp.810-824. ⟨10.1093/nsr/nwz049⟩
Ostrander, Elaine A; Wang, Guo-Dong; Larson, Greger; vonHoldt, Bridgett M; Davis, Brian W; Jagannathan, Vidya; Hitte, Christophe; Wayne, Robert K; Zhang, Ya-Ping (2019). Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. National Science Review, 6(4), pp. 810-824. Oxford University Press 10.1093/nsr/nwz049
National Science Review, 2019, 6 (4), pp.810-824. ⟨10.1093/nsr/nwz049⟩
ISSN: 2095-5138
Popis: Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health. This work was supported by a number of entities including grants from the Breakthrough Project of the Strategic Priority Program of the Chinese Academy of Sciences (CAS) (XDB13000000 to G-DW); the National Natural Science Foundation of China (91731304, 31621062); the Intramural Program of the National Human Genome Research Institute of the National Institutes of Health, USA (to EAO); a CAS international collaborating grant proposal (152453KYSB20150002 to G-DW); the Morris Animal Foundation (to RKW); the Swedish Research Council (to KLT); the European Research Council (ERC-2013-StG-337574-UNDEAD to GL and LF); the Natural Environmental Research Council (NE/K005243/1 and NE/K003259/1 to GL and LF); grant ‘Cani-DNA_CRB’ (ANR-11-INBS-0003) for the French Tissue Bank (to CA and CH); and a Young Innovation Promotion Association Award (to G-DW).
Databáze: OpenAIRE
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