Basal hyperaemia is the primary abnormality of perfusion in Takotsubo cardiomyopathy: a quantitative cardiac perfusion positron emission tomography study
| Autor: | Kiril Aleksov Ahtarovski, Nikolaj Ihlemann, Andreas Kjaer, Thomas Emil Christensen, Philip Hasbak, Lene Holmvang, Adam Ali Ghotbi, Niels Vejlstrup, Thomas Engstrøm, Helle Søholm, Hedvig Bille Andersson, Lia Evi Bang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Cardiomyopathy Perfusion scanning Hyperemia Coronary Angiography Hyperaemia Myocardial perfusion imaging Electrocardiography Ventricular Dysfunction Left Cardiac magnetic resonance imaging Takotsubo Cardiomyopathy Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Aged medicine.diagnostic_test business.industry Myocardial Perfusion Imaging Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Echocardiography Heart failure Positron-Emission Tomography Cardiology Female medicine.symptom Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Perfusion Rubidium Radioisotopes Biomarkers |
| Zdroj: | European heart journal. Cardiovascular Imaging. 16(10) |
| ISSN: | 2047-2412 |
| Popis: | Aims Takotsubo cardiomyopathy (TTC) is characterized by acute completely reversible regional left ventricle (LV) akinesia and decreased tracer uptake in the akinetic region on semi-quantitative perfusion imaging. The latter may be due to normoperfusion of the akinetic mid/apical area and basal hyperperfusion. Our aim was to examine abnormalities of perfusion in TTC, and we hypothesized that basal hyperperfusion is the primary perfusion abnormality in the acute state. Method and results Twenty-five patients were diagnosed with TTC due to (i) acute onset of symptoms, (ii) typical apical ballooning, (iii) absence of significant coronary disease, and (iv) complete remission on 4-month follow-up. The patients underwent coronary angiography (CAG), echocardiography, cardiac magnetic resonance imaging (CMR), and 13NH3/82Rb positron emission tomography (PET) in the acute state and—except CAG—on follow-up. Patients initially had severe heart failure, mid/apical oedema but no infarction, and a rise in cardiac biomarkers. On initial perfusion PET imaging, eight patients appeared to have normal, whereas 17 patients had impaired LV perfusion. In the latter, flow in the basal region was increased in the acute state (1.5 ± 0.1 vs. 1.2 ± 0.1 mL/g/minRPP−corrected, P < 0.01), whereas midventricular (1.7 ± 0.1 vs. 1.6 ± 0.1 mL/g/minRPP−corrected, P = 0.21) and apical (1.4 ± 0.1 vs. 1.5 ± 0.1 mL/g/minRPP−corrected, P = 0.36) flow was unchanged between acute and follow-up, and within normal range. Conclusion Our results suggest an abnormal LV perfusion distribution in the acute state of TTC with basal hyperperfusion and a normoperfused akinetic region. The proportion of patients without visualized perfusion abnormalities in the acute state may represent a subgroup with fast remission. |
| Databáze: | OpenAIRE |
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