Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia
| Autor: | Dong Eun Lee, Chul-Sung Huh, Sim Jae Hun, Il Dong Choi, Sung Hwan Kim, Young-Tae Ahn, Seong Soo Hong, Ji Woong Jeong |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein B Normal diet Diet High-Fat Applied Microbiology and Biotechnology Microbiology law.invention 03 medical and health sciences Probiotic chemistry.chemical_compound law Glycerol medicine Animals Humans Food science Rats Wistar Triglycerides Hypertriglyceridemia biology Triglyceride Probiotics food and beverages General Medicine biology.organism_classification medicine.disease G protein-coupled bile acid receptor Rats Disease Models Animal Lactobacillus 030104 developmental biology Liver chemistry Dietary Supplements biology.protein lipids (amino acids peptides and proteins) Lactobacillus plantarum Biotechnology |
| Zdroj: | Journal of Microbiology and Biotechnology. 26:483-487 |
| ISSN: | 1738-8872 1017-7825 |
| Popis: | The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR. |
| Databáze: | OpenAIRE |
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