Maturation of Mitochondrial and other Isoenzymes of Creatine Kinase in Skeletal Muscle of Preterm Born Infants
Autor: | T v Lith, Ron A. Wevers, Frans J.M. Trijbels, R. C. A. Sengers, Wolfgang Sperl, R.M. de Graaf, J. A. M. Smeitink, Wim Ruitenbeek |
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Rok vydání: | 1992 |
Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Clinical Biochemistry 030209 endocrinology & metabolism Citrate (si)-Synthase Electron Transport Complex IV 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Creatine Kinase Pregnancy Fetus biology Kinase Infant Newborn Skeletal muscle General Medicine medicine.disease Prenatal development Mitochondria Muscle Isoenzymes Cytosol Endocrinology medicine.anatomical_structure biology.protein Female Specific activity Creatine kinase Infant Premature |
Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 29:302-306 |
ISSN: | 1758-1001 0004-5632 |
DOI: | 10.1177/000456329202900309 |
Popis: | We studied pre- and postnatal changes in total creatine kinase (CK) activity, mitochondrial creatine kinase (Mi-CK) activity and immunochemical reactivity with anti-Mi-CK antibodies in skeletal muscle specimens from 12 infants, 10 of them preterm born, after a pregnancy varying between 28 and 40 weeks. Our results demonstrate that Mi-CK is present in fetal human quadriceps muscle and that the specific activity of Mi-CK increases during prenatal development from week 28 to 40 by a factor about two. Generally, adult levels have not been reached at birth, indicating a further postnatal increase of the activity of the enzyme. The Mi-CK protein content also increases during prenatal development. These results suggest that in human skeletal muscle the expression and accumulation of Mi-CK starts at mid-gestation, later than is known to occur for cytosolic CK. |
Databáze: | OpenAIRE |
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