Maturation of Mitochondrial and other Isoenzymes of Creatine Kinase in Skeletal Muscle of Preterm Born Infants

Autor: T v Lith, Ron A. Wevers, Frans J.M. Trijbels, R. C. A. Sengers, Wolfgang Sperl, R.M. de Graaf, J. A. M. Smeitink, Wim Ruitenbeek
Rok vydání: 1992
Předmět:
Zdroj: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 29:302-306
ISSN: 1758-1001
0004-5632
DOI: 10.1177/000456329202900309
Popis: We studied pre- and postnatal changes in total creatine kinase (CK) activity, mitochondrial creatine kinase (Mi-CK) activity and immunochemical reactivity with anti-Mi-CK antibodies in skeletal muscle specimens from 12 infants, 10 of them preterm born, after a pregnancy varying between 28 and 40 weeks. Our results demonstrate that Mi-CK is present in fetal human quadriceps muscle and that the specific activity of Mi-CK increases during prenatal development from week 28 to 40 by a factor about two. Generally, adult levels have not been reached at birth, indicating a further postnatal increase of the activity of the enzyme. The Mi-CK protein content also increases during prenatal development. These results suggest that in human skeletal muscle the expression and accumulation of Mi-CK starts at mid-gestation, later than is known to occur for cytosolic CK.
Databáze: OpenAIRE
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