Indexes of β-cell function from the oral glucose tolerance test can modestly predict pancreatic β-cell area in Korean
| Autor: | Soo Kyoung Kim, Jae Hyeon Kim, Kwang-Won Kim, Jin Seok Heo, Ji Young Park, Seong Ho Choi, Kee-Taek Jang, Hee Sung No, Dong Wook Choi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty β cell function Endocrinology Diabetes and Metabolism Cell Impaired glucose tolerance Prediabetic State Endocrinology Internal medicine Diabetes mellitus Insulin-Secreting Cells Glucose Intolerance Internal Medicine medicine Diabetes Mellitus Homeostasis Humans Oral glucose tolerance Pancreas Aged Korea business.industry General Medicine Glucose Tolerance Test Middle Aged medicine.disease Impaired fasting glucose medicine.anatomical_structure Female Insulin Resistance business |
| Zdroj: | Diabetes research and clinical practice. 93(2) |
| ISSN: | 1872-8227 |
| Popis: | Aims Pancreatic β-cell function indexes have been suggested using the oral glucose tolerance test (OGTT). Here, we investigated whether β-cell function index from the OGTT reflects pancreatic β-cell area in Korean patients. Methods The study consisted of 45 patients who underwent pancreatectomies. Before operation, a 75-g OGTT was performed. Immunohistochemical staining was performed, and indexes of β-cell function from the OGTT data were compared with the pancreatic β-cell area. Results The β-cell area of the pancreas was 1.07 ± 0.33% in the normal glucose tolerance group, 1.71 ± 0.85% in the pre-diabetes group (impaired glucose tolerance and impaired fasting glucose), and 1.08 ± 0.57% in the diabetes group. The β-cell area of the pre-diabetes group was significantly higher than that of the diabetes group. Pancreatic β-cell area showed a significant correlation with a homeostasis model assessment of β-cell function (r = 0.358, P = 0.016), disposition index (r = 0.336, P = 0.024), fasting glucose (r = −0.359, P = 0.015), and the C-peptide/glucose 30 min ratio (r = 0.319, P = 0.035). Conclusions Some parameters of β-cell function from the OGTT showed a significant relationship with the β-cell area of pancreas. |
| Databáze: | OpenAIRE |
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