Extramedullary relapse in a patient with multiple myeloma: a rare cause of gastrointestinal perforation and massive bleeding
Autor: | Michael Patrick Achiam, Christoffer Galletta Rene, Luit Penninga, Morten Salomo |
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Rok vydání: | 2023 |
Předmět: |
Billroth II
Male medicine.medical_specialty Palliative care Bortezomib business.industry medicine.medical_treatment Perforation (oil well) General Medicine medicine.disease Surgery Gastrointestinal perforation medicine Plasmacytoma Humans Gastrectomy Prospective Studies Neoplasm Recurrence Local business Multiple Myeloma Multiple myeloma medicine.drug Aged |
Zdroj: | BMJ case reports. 14(11) |
ISSN: | 1757-790X |
Popis: | Multiple myeloma (MM) patients live longer due to more effective treatment, and we now see previously uncommon manifestations of MM, like extramedullary disease. We present a case of a 74-year-old man known with MM that relapsed with extramedullary manifestations at different locations. One of them as a gastric plasmacytoma (GP). He was successfully treated with chemoradiotherapy (Daratumumab, Bortezomib and Dexamethasone), which resulted in clinical response for 8 months, confirmed by biopsy and histopathology. Perforation of the GP occurred, and he underwent partial gastrectomy (Billroth II gastrojejunostomy). The patient’s disease progressed again 5 months after surgery, and he did not want any additional treatment. He accepted palliative care and died 10 months after the operation. A lack of knowledge about the characteristics and treatment of extramedullary MM exists, and prospective studies to investigate incidence, prognosis and treatment for extramedullary MM are needed for improving the poor prognosis of this manifestation. |
Databáze: | OpenAIRE |
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