Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden
| Autor: | Garry Burdett, Clare Gilham, John T. Hodgson, Christine Rake, Julian Peto, Leslie Davison, Angelo Franchini, Andrew G. Nicholson, Andrew Darnton, James R. Carpenter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Asbestosis Population medicine.disease_cause Asbestos Environmental & Occupational Health 03 medical and health sciences 0302 clinical medicine Environmental health Chrysotile medicine Pleural Neoplasm Mesothelioma Lung cancer education education.field_of_study business.industry Public Health Environmental and Occupational Health 1103 Clinical Sciences Environmental exposure respiratory system medicine.disease 030210 environmental & occupational health respiratory tract diseases 1117 Public Health And Health Services 030220 oncology & carcinogenesis 1599 Other Commerce Management Tourism And Services business |
| ISSN: | 1351-0711 |
| Popis: | BACKGROUND: We have conducted a population-based study of pleural mesothelioma patients with occupational histories and measured asbestos lung burdens in occupationally exposed workers and in the general population. The relationship between lung burden and risk, particularly at environmental exposure levels, will enable future mesothelioma rates in people born after 1965 who never installed asbestos to be predicted from their asbestos lung burdens. METHODS: Following personal interview asbestos fibres longer than 5 µm were counted by transmission electron microscopy in lung samples obtained from 133 patients with mesothelioma and 262 patients with lung cancer. ORs for mesothelioma were converted to lifetime risks. RESULTS: Lifetime mesothelioma risk is approximately 0.02% per 1000 amphibole fibres per gram of dry lung tissue over a more than 100-fold range, from 1 to 4 in the most heavily exposed building workers to less than 1 in 500 in most of the population. The asbestos fibres counted were amosite (75%), crocidolite (18%), other amphiboles (5%) and chrysotile (2%). CONCLUSIONS: The approximate linearity of the dose-response together with lung burden measurements in younger people will provide reasonably reliable predictions of future mesothelioma rates in those born since 1965 whose risks cannot yet be seen in national rates. Burdens in those born more recently will indicate the continuing occupational and environmental hazards under current asbestos control regulations. Our results confirm the major contribution of amosite to UK mesothelioma incidence and the substantial contribution of non-occupational exposure, particularly in women. |
| Databáze: | OpenAIRE |
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