Assessment of male reproductive system in the CD-1 mice following oral manganese exposure
| Autor: | Karen A. Graves, Karen S. Bailey, Tulasi Ponnapakkam, Marcus B. Iszard |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Administration Oral Semen Mice Inbred Strains Biology Toxicology Andrology Mice Seminal vesicle Internal medicine Testis medicine Animals Manganese Poisoning Sperm motility Epididymis Manganese Dose-Response Relationship Drug Sperm Count urogenital system Reproduction Body Weight Seminal Vesicles Organ Size Sperm Dose–response relationship Endocrinology medicine.anatomical_structure Fertility Toxicity Sperm Motility |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 17(5) |
| ISSN: | 0890-6238 |
| Popis: | Manganese has wide industrial applications and exposure to manganese can result in serious health conditions. The purpose of this study was to determine the reproductive effect of oral manganese exposure in male mice. Manganese acetate was tested at three dose levels (7.5, 15.0, and 30.0 mg/kg/day) for 43 days. The control group (0 mg/kg/day) received distilled water. Control negative group did not receive anything. Reproductive organ weights were recorded. Histopathology was performed on right testis, epididymis, seminal vesicle, and the accessory glands. Cauda epididymal, testicular sperm counts, and sperm motility was evaluated on the organ from the left side. The results of this study suggest that exposure to manganese caused a statistically significant (P |
| Databáze: | OpenAIRE |
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