Hemodynamic effects of the use of oral snuff
| Autor: | Thomas Hedner, Jan Hedner, Jan M. Lundberg, Jan-Michaél Hirsch, Lars Wernstedt |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Tobacco Smokeless Rest Hemodynamics Blood Pressure Norepinephrine (medication) Nicotine chemistry.chemical_compound Catecholamines Heart Rate Reference Values Internal medicine Heart rate medicine Humans Neuropeptide Y Pharmacology (medical) Snuff Exercise Pharmacology business.industry Plants Toxic Endocrinology Blood pressure Epinephrine chemistry Female business Cotinine medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 52:394-401 |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | The hemodynamic effects during rest and exercise of oral snuff were investigated in an open, placebo-controlled study of nine habitual users of oral snuff. Blood pressure, heart rate, and central hemodynamics were measured noninvasively. Plasma concentrations of nicotine, cotinine, norepinephrine, and epinephrine, as well as neuropeptide Y-like immunoreactivity were measured before and after snuff intake during rest and exercise. Snuff intake induced a significant increase in heart rate and blood pressure and a decrease in stroke volume during rest. Hemodynamic changes were unrelated to nicotine or cotinine concentrations. Resting levels of norepinephrine and neuropeptide Y-like immunoreactivity were similar with or without snuff, whereas epinephrine was slightly increased 30 minutes after snuff intake. The exercise-induced increase in norepinephrine and neuropeptide Y-like immunoreactivity did not differ between the days subjects received snuff and the days they received placebo. In contrast, maximum work load was associated with a slight increase in circulating epinephrine after snuff intake. The findings suggest that snuff intake is associated with significant hemodynamic effects during rest but not during exercise. These effects could not be readily explained by activation of the sympathetic nervous system. |
| Databáze: | OpenAIRE |
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