A Fast 0.5 T Prepolarizer Module for Preclinical Magnetic Resonance Imaging
| Autor: | Jose M. Algarin, R. Bosch, D. Grau-Ruiz, Alfonso Rios, J. Alonso, J. Borreguero, José Manuel Rodríguez González, Eduardo Pallas, Juan V. Sanchez-Andres, Ruben Pellicer, Jose M. Benlloch, J. P. Rigla, C. Gramage, Fernando Galve |
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| Rok vydání: | 2022 |
| Předmět: |
prepolarization
010302 applied physics low field Physics - Instrumentation and Detectors Materials science medicine.diagnostic_test Electromagnet magnet design FOS: Physical sciences Magnet design Magnetic resonance imaging Instrumentation and Detectors (physics.ins-det) electromagnet Physics - Medical Physics 01 natural sciences Electronic Optical and Magnetic Materials Nuclear magnetic resonance Low field Prepolarization 0103 physical sciences medicine Medical Physics (physics.med-ph) Electrical and Electronic Engineering MRI |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I IEEE Transactions on Magnetics RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| ISSN: | 1941-0069 0018-9464 |
| DOI: | 10.1109/tmag.2021.3080840 |
| Popis: | [EN] We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological tissues. The sensitivity of MRI systems grows with field strength, but so do their costs. PMRI can boost the signal-to-noise ratio (SNR) in affordable low-field scanners by means of a long and strong magnetic pulse. However, this must be rapidly switched off prior to the imaging pulse sequence, in timescales shorter than the spin relaxation (or T1) time of the sample. We have operated our prepolarizer at up to 0.5 T and demonstrated enhanced magnetization, image SNR and tissue contrast with PMRI of tap water, an ex vivo mouse brain and food samples. These have T1 times ranging from hundreds of milli-seconds to single seconds, while the preliminary high-power electronics setup employed in this work can switch off the prepolarization field in tens of milli-seconds. In order to make this system suitable for solid-state matter and hard tissues, which feature T1 times as short as 10 ms, we are developing new electronics which can cut switching times to ~ 300 ¿s. This does not require changes in the prepolarizer module, opening the door to the first experimental demonstration of PMRI on hard biological tissues. This work was supported in part by the European Commission under Grant 737180 (FET-Open: HistoMRI), in part by the Ministerio de Ciencia e Innovación of Spain for Research under Grant PID2019-111436RB-C21, and in part by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014¿2020 under Grant IDIFEDER/2018/022. The work of José M. González was supported by the Innodocto Program of the Agencia Valenciana de la Innovación under Grant INNTA3/2020/22. The work of Juan V. Sanchez-Andres was supported by the Universitat Jaume I - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (UJISABIO) under Grant 21I044.01/1 |
| Databáze: | OpenAIRE |
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