Viscous control of cellular respiration by membrane lipid composition

Autor:	Christopher J. Petzold, Tristan de Rond, Leanne Jade G. Chan, Yan Chen, Itay Budin, Jay D. Keasling
Rok vydání:	2018
Předmět:	0301 basic medicine chemistry.chemical_classification Multidisciplinary Viscosity Cellular respiration Cell Membrane 030106 microbiology Biological membrane medicine.disease_cause Electron transport chain Mitochondria Oxygen Membrane Lipids 03 medical and health sciences 030104 developmental biology Enzyme Membrane chemistry Escherichia coli Fatty Acids Unsaturated medicine Biophysics Inner membrane
Zdroj:	Science. 362:1186-1189
ISSN:	1095-9203 0036-8075
Popis:	How membrane viscosity affects respiration In bacteria, energy production by the electron transport chain occurs at cell membranes and can be influenced by the lipid composition of the membrane. Budin et al. used genetic engineering to influence the concentration of unsaturated branched-chain fatty acids and thus control membrane viscosity (see the Perspective by Schon). Experimental measurements and mathematical modeling indicated that rates of respiratory metabolism and rates of cell growth were dependent on membrane viscosity and its effects on diffusion. Experiments on yeast mitochondria also showed similar effects. Maintaining efficient respiration may thus place evolutionary constraints on cellular lipid composition. Science , this issue p. 1186 ; see also p. 1114
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e46fe8edc6bc690a61aace6aa30613 https://doi.org/10.1126/science.aat7925 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.