Response of antioxidant defences to oxidative stress induced by prolonged exercise: antioxidant enzyme gene expression in lymphocytes
| Autor: | Josep A. Tur, Antoni Pons, Isabel Maestre, Antoni Sureda, Alfredo Córdova, Enrique Roche, Antoni Aguiló, Pedro Tauler, Nuria Cases |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Serum medicine.medical_specialty Antioxidant Physiology medicine.medical_treatment Lymphocyte Physical exercise medicine.disease_cause Antioxidants Superoxide dismutase Physiology (medical) Internal medicine Gene expression medicine Humans Vitamin E Orthopedics and Sports Medicine Lymphocytes Exercise chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Chemistry Public Health Environmental and Occupational Health General Medicine Catalase Carotenoids Oxidative Stress Endocrinology medicine.anatomical_structure Enzyme biology.protein Biomarkers Oxidative stress |
| Zdroj: | European Journal of Applied Physiology. 98:263-269 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-006-0273-y |
| Popis: | The response of lymphocyte and plasma antioxidant defences to a prolonged exercise as a cycling stage in a professional race was analysed. Antioxidant enzyme activities and gene expression, carbonyl derivative and MDA levels were determined in lymphocytes. Plasma levels of vitamin E, carotenes, protein carbonyl derivatives and the test d-Roms were measured. Significant increases in plasmatic carbonyls and in the test d-Roms were observed after the cycling stage. No significant differences were found in the lymphocyte MDA and carbonyl derivative levels. A significant increase was found in plasma vitamin E concentration after the cycling stage; however, the lymphocyte vitamin E concentration did not change. Significant increases were observed in lymphocyte total superoxide dismutase (SOD) activity and in the levels of CuZn-SOD and Mn-SOD isoenzymes. The moderate levels of oxidative stress in the lymphocyte induced a cellular adaptation to exercise enough to counteract the negative effects of oxidative stress. |
| Databáze: | OpenAIRE |
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