The impact of ischaemic preconditioning on spinal cord blood flow and paraplegia
| Autor: | Yukio Okazaki, T Ueno, Zhi-Li Chao, Tsuyoshi Itoh |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Paraplegia
Aorta business.industry Blood flow medicine.disease Spinal cord blood flow Disease Models Animal Mean blood pressure Spinal Cord Regional Blood Flow Reperfusion Injury Anesthesia medicine.artery medicine Spastic Animals Ischemic preconditioning Radiology Nuclear Medicine and imaging Surgery Rabbits Ischemic Preconditioning Cardiology and Cardiovascular Medicine business Spinal cord injury |
| Zdroj: | Cardiovascular Surgery. 9:575-579 |
| ISSN: | 0967-2109 |
| DOI: | 10.1016/s0967-2109(01)00083-7 |
| Popis: | Purpose: We investigated the effect of ischaemic preconditioning (IP) on ischaemic spinal cord injury in a rabbit model. Methods: Fourteen rabbits were divided into IP and control groups of seven rabbits each. We repeated 3-min clamping of the infrarenal abdominal aorta and 3-min reperfusion twice (preconditioning), followed by 15 min clamping in the IP group. In the control group, the aorta was clamped for 15 min without preconditioning. Lumbar cord blood flow and systemic blood pressure were measured until 3 h of reperfusion. Another 14 rabbits underwent the same procedures with or without IP and neurologic status was assessed on the second postoperative day. Results: The percent change in lumbar cord blood flow after reperfusion was significantly greater (P=0.013) in the IP group despite lower mean blood pressure. There was no significant difference in overall neurologic status (P=0.461) but the incidence of spastic paraplegia in the IP group was lower (14%, 1/7) than that of control group (43%, 3/7). Conclusion: IP increased postischaemic lumbar cord blood flow and contributed to lower incidence of spastic paraplegia. |
| Databáze: | OpenAIRE |
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