Fentanyl iontophoretic transdermal system versus morphine intravenous patient-controlled analgesia for pain management following orthopedic surgery: A pooled analysis of randomized, controlled trials
| Autor: | Craig T Hartrick, Li Ding, Hassan Danesi, Donald M Knapke, James B Jones |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment 030204 cardiovascular system & hematology Administration Cutaneous law.invention Fentanyl 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Acute care medicine Humans Orthopedic Procedures Pharmacology (medical) Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Aged 80 and over Pain Postoperative Morphine Patient-controlled analgesia business.industry Analgesia Patient-Controlled General Medicine Iontophoresis Middle Aged Surgery Analgesics Opioid Anesthesiology and Pain Medicine Anesthesia Orthopedic surgery Female business medicine.drug Intravenous Patient-Controlled Analgesia |
| Zdroj: | Journal of Opioid Management. 12:37-45 |
| ISSN: | 1551-7489 |
| DOI: | 10.5055/jom.2016.0310 |
| Popis: | Objective: To compare the efficacy and safety of patient-controlled pain management following orthopedic surgery using either fentanyl iontophoretic transdermal system (ITS) or morphine intravenous (IV) patient-controlled analgesia (PCA) . Setting: Acute Care Hospital . Patients: Three-open-label, multicenter, randomized, active-controlled, parallel-group phase 3B studies (N = 2095) were conducted that compared fentanyl ITS with morphine IV PCA for postoperative pain in hospitalized postoperative patients. A subgroup of orthopedic surgery patients (N = 1,216) was pooled for this analysis; of which 819 completed treatment . Interventions: A total of 590 patients received fentanyl ITS (40 μg/dose) and 626 patients received morphine IV PCA (1 mg/dose) for up to 72 hours . Main outcome measures: Efficacy measures included the patient global assessment (PGA) and the investigator global assessment (IGA) of the method of pain control . Results: Patients had a mean age of about 60 years, were predominantly Caucasian (90.5 percent), and the majority underwent hip replacement (80.3 percent). There were more patients treated with fentanyl ITS who rated their pain control method as “excellent” compared to morphine IV PCA at 24 hours postsurgery (44.8 percent vs 33.0 percent, respectively; p < 0.001), 48 hours (37.5 percent vs 25.3 percent, respectively; p < 0.001), and at the last assessment (54.3 percent vs 39.6 percent, respectively; p < 0.001). There were more investigators who rated treatment with fentanyl ITS as “excellent” compared to morphine IV PCA at the last assessment (57.4 percent vs 36.9 percent, respectively; p < 0.001) . Conclusions: Following orthopedic surgery, patients and investigators more frequently reported global assessment of pain control as “excellent” on the PGA and IGA assessments with fentanyl ITS than with morphine IV PCA . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|