Drug loss while crushing tablets: Comparison of 24 tablet crushing devices
| Autor: | Kathryn J. Steadman, Yady J. Manrique, Min Yew Thong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug Administration
Materials science Materials by Structure Drug Compounding Materials Science Administration Oral lcsh:Medicine 030226 pharmacology & pharmacy Consumer Electronics 03 medical and health sciences 0302 clinical medicine Drug Therapy Drug Stability Animal Products Medicine and Health Sciences Humans 030212 general & internal medicine lcsh:Science Nutrition Acetaminophen Pharmacology Drug compounding Multidisciplinary Pharmaceutics Physics lcsh:R Biology and Life Sciences Drugs Drug administration Agriculture Honey Acoustics Pulp and paper industry Crusher Diet Quiet surgical procedures operative Food Physical Sciences Engineering and Technology Medical Devices and Equipment lcsh:Q Powders Electronics Drug Delivery Research Article Biotechnology Tablets |
| Zdroj: | PLoS ONE, Vol 13, Iss 3, p e0193683 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0193683 |
| Popis: | This study investigated 24 tablet crushing devices for drug loss using different methods to recover the crushed tablet. 24 devices were compared: 3 with disposable cups, 6 with disposable bags, 12 without separate vessels and 3 types of mortar and pestle. One paracetamol tablet was crushed and recovered by tapping the powder out. Where appropriate, depending on crusher size and manufacturer instructions, the powder was also recovered by mixing with water or food. Paracetamol recovery (quantity that can be delivered to a patient) and leftover (quantity remaining in the device) were measured using a validated UV method and the entire experiment was replicated 3 times. Drug recovery ranged from 86.7-98.1% when the crushed tablet was tapped out of the crushers (average loss 5.8%). Significant losses were measured for 18 crushers, particularly manually operated hand-twist crushers with a serrated crushing surface, and some devices with disposable bags or cups. Rinsing the crushed powder with water once resulted in an average of 24.2% drug loss, and this was reduced to 4.2% after a second rinse. If crushing is unavoidable, maximizing medication delivery to the patient is essential. Rinsing twice resulted in similar paracetamol recovery to tapping the powder out; however only water rinses have the potential for direct consumption by the patient, minimizing drug loss across the entire crushing and transfer process. |
| Databáze: | OpenAIRE |
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