Using longitudinal data to define the perimenopause by menstrual cycle characteristics
| Autor: | Henry G. Burger, J R Guthrie, John L. Hopper, Emma Dudley, Lorraine Dennerstein, John Taffe |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.drug_class media_common.quotation_subject Menstruation Follicle-stimulating hormone medicine Humans Inhibins Longitudinal Studies Amenorrhea Menstrual Cycle Menstrual cycle media_common Gynecology Estradiol Obstetrics business.industry Australia Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Menopause Clinical research Estrogen Hot Flashes Female sense organs medicine.symptom business Hormone |
| Zdroj: | Climacteric. 1:18-25 |
| ISSN: | 1473-0804 1369-7137 |
| Popis: | To determine which aspects of menstrual change best predict time to postmenopause.A total of 250 Australian-born women aged 45-55 years were divided into five menstrual status categories: Group I reported no change in menstrual flow or frequency; Group II reported change in flow; Group III reported change in frequency; Group IV reported change in both frequency and flow; and Group V reported between 3 and 11 months of amenorrhea. Menstrual status groups were compared on baseline data for age, hormone levels, hot flushes and self-rated menopausal status. The proportion of women moving to postmenopause in subsequent years was compared using 4 years of follow-up data.Women in Group V were older, had lower estradiol and inhibin levels, higher follicle stimulating hormone levels, and were more likely to report hot flushes, and to self-rate themselves as having started the menopausal transition, compared with the women who had menstruated in the last 3 months (Groups I-IV). Groups I and II were similar in age and hormonal status, as were Groups III and IV. The proportion of women who had moved to postmenopausal status in the 4 years after baseline were 12%, 14%, 58%, 53% and 94% for Groups I-V, respectively.Amenorrhea is the best predictor of future menopause followed by changes in menstrual frequency. Change in flow only was not predictive of future menopause. A two-stage classification scheme is suggested for defining the perimenopause. 'Early perimenopause' is defined as the self-reporting of changes in menstrual frequency over the last year, and 'late perimenopause' is defined as the self-report of 3-11 months of amenorrhea. |
| Databáze: | OpenAIRE |
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