Changes in thyroid function after bone marrow transplant in young patients
| Autor: | Hiromasa Yabe, Masae Matsumoto, Shimizu Takashi, Osamu Shinohara, Hiroyasu Inoue, Shunichi Kato, Yukiharu Yasuda, Yuichirou Tomita, Tsuyoshi Shinagawa, Hiroyuki Ishiguro, Miharu Yabe, K Hattori, Chidori Kubota |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Thyroid Hormones Time Factors Transplantation Conditioning endocrine system diseases Adenoma Adolescent Thyroid Gland Thyroid Function Tests Gastroenterology Thyroid function tests TRH stimulation test Hypothyroidism Internal medicine medicine Compensated Hypothyroidism Humans Child Thyrotropin-Releasing Hormone Bone Marrow Transplantation medicine.diagnostic_test business.industry Thyroid Primary hypothyroidism Infant medicine.disease Euthyroid Sick Syndromes surgical procedures operative Endocrinology medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Female Thyroid function business hormones hormone substitutes and hormone antagonists Euthyroid sick syndrome Follow-Up Studies |
| Zdroj: | Pediatrics international : official journal of the Japan Pediatric Society. 46(3) |
| ISSN: | 1328-8067 |
| Popis: | Background: Changes in thyroid function among young patients who received bone marrow transplantation (BMT) were evaluated. Methods: The study included 91 patients (50 males) who underwent BMT from 1985 to 1995 at the age of 0.6−21 years. Sixty patients had neoplastic disease such as leukemia or lymphoma, and the remainder had non-neoplastic diseases. Preconditioning regimen for BMT included 12 Gy of fractionated-total body irradiation (TBI) for patients with neoplastic disease and 3−8 Gy of irradiation for the remaining patients, in addition to chemotherapy. Evaluation of thyroid function was performed by serial assessment of basal serum FT4, FT3, TSH concentrations as well as by TRH test. Results: No patient had overt hypothyroidism or elevated basal TSH concentrations (>10 mU/L). However, 6 (7%) of patients experienced exaggerated peak TSH response to TRH stimulation several years after BMT. In 33 patients whose thyroid status was evaluated before, within 3 months, and 1 year after BMT, serum FT3 concentrations as well as peak TSH response to TRH stimulation significantly decreased immediately after BMT ( |
| Databáze: | OpenAIRE |
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