pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration
| Autor: | Cao, Shoupeng, Abdelmohsen, Loai K.E.A., Shao, Jingxin, Van Den Dikkenberg, Joep, Mastrobattista, Enrico, Williams, David S., Van Hest, Jan C.M., Afd Pharmaceutics, Pharmaceutics |
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| Přispěvatelé: | Afd Pharmaceutics, Pharmaceutics, Bio-Organic Chemistry, Macromolecular and Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Letter Polymers and Plastics Organic Chemistry Cationic polymerization technology industry and agriculture Nanoparticle 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Chemical engineering chemistry Polymerization Copolymer Materials Chemistry Surface charge Trimethylene carbonate 0210 nano-technology Ethylene glycol |
| Zdroj: | ACS Macro Letters ACS Macro Letters, 7(11), 1394. American Chemical Society ACS Macro Letters, 7(11), 1394-1399. American Chemical Society |
| ISSN: | 2161-1653 |
| Popis: | Herein we describe biodegradable nanovectors comprised of block copolymers of poly(ethylene glycol) and poly(trimethylene carbonate) (PEG-PTMC) that change their morphology and surface charge when exposed to tumor environment conditions. Well-defined, drug-loaded nanovectors were prepared via direct hydration using liquid oligo(ethylene glycol) as a dispersant. Systematic introduction of basic imidazole-functional TMC derivatives, through modular polymerization, resulted in polymers that self-assembled in multilamellar nanoparticles (at neutral pH) and that were loaded with hydrophobic drugs. The resultant multilamellar nanovectors demonstrated a significant size reduction and charge reversal at pH ≈ 6.5, which yielded cationic nanovectors that were tailored for tumor penetration. In vitro studies using 3D heterospheroids demonstrate that this platform has excellent potential to promote enhanced tumor penetration under physiological conditions. |
| Databáze: | OpenAIRE |
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