Nutritional Intervention in Malnourished Hospitalized Patients with Heart Failure
| Autor: | Rosa Alhambra Expósito, Juan L. Bonilla-Palomas, Mirian Moreno-Conde, Antonia Villar-Ráez, Antonio L. Gámez-López, María Cristina López Ibáñez, Juan C. Castillo-Domínguez, Esmeralda Ramiro Ortega, Manuel Anguita-Sánchez |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Risk medicine.medical_specialty Nutritional Status 030204 cardiovascular system & hematology Patient Readmission 03 medical and health sciences 0302 clinical medicine Internal medicine Intervention (counseling) medicine Clinical endpoint Humans 030212 general & internal medicine Mortality Intensive care medicine Aged Aged 80 and over Heart Failure Inpatients Intention-to-treat analysis business.industry Malnutrition Hazard ratio General Medicine medicine.disease Confidence interval Clinical trial Heart failure Acute Disease Female business |
| Zdroj: | Archives of Medical Research. 47:535-540 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2016.11.005 |
| Popis: | Background and Aims Hospitalized patients with heart failure who are malnourished present a worse prognosis than those with an adequate nutritional status. We undertook this study to assess whether a nutritional intervention in malnourished hospitalized patients with heart failure benefits morbidity and mortality. Methods A multicenter, randomized, controlled clinical trial was conducted. A total of 120 malnourished hospitalized patients due to acute heart failure were randomised to conventional heart failure treatment or conventional heart failure treatment combined with an individualized nutritional intervention. The primary endpoint of this study was a composite of all-cause death or readmission for worsening of HF, with a maximum follow-up of 12 months. Analysis was by intention to treat. Results Recruitment was stopped early according to the study protocol after completing the follow-up of the first 120 patients enrolled (59 in the intervention group and 61 in the control group). Both groups were homogeneous in baseline characteristics. At 12 months, the primary outcome occurred in 27.1% of patients in the intervention group and in 60.7% of patients in the control group (hazard ratio 0.45; 95% confidence interval [CI], 0.19–0.62, p = 0.0004). In total, 20.3% of patients died in the intervention group and 47.5% in the control group (hazard ratio 0.37, 95% CI, 0.19–0.72, p = 0.003). Readmission due to heart failure was also lower in the intervention group (10.2 vs. 36.1%, p = 0.001). Conclusion Nutritional intervention in malnourished hospitalized patients with heart failure reduces the risk of death from any cause and the risk of readmission for worsening of heart failure ( ClinicalTrial.gov NCT01472237 ). |
| Databáze: | OpenAIRE |
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