Neurofeedback Training Effects on Inhibitory Brain Activation in ADHD: A Matter of Learning?

Autor: Daniel Brandeis, Tobias Banaschewski, Sarah Baumeister, Regina Boecker-Schlier, Isabella Wolf, Nicoletta Adamo, Sarah Hohmann, Martin Holtmann, Nathalie E. Holz, Matthias Ruf
Přispěvatelé: University of Zurich, Brandeis, Daniel
Rok vydání: 2018
Předmět:
Male
Brain activation
medicine.medical_specialty
Adolescent
medicine.medical_treatment
education
610 Medicine & health
Audiology
Inhibitory postsynaptic potential
Biofeedback
behavioral disciplines and activities
050105 experimental psychology
Self-Control
Developmental psychology
03 medical and health sciences
0302 clinical medicine
Inhibitory control
medicine
Humans
Learning
0501 psychology and cognitive sciences
10064 Neuroscience Center Zurich
Child
medicine.diagnostic_test
Electromyography
General Neuroscience
05 social sciences
Brain
2800 General Neuroscience
Electroencephalography
Neurofeedback
10058 Department of Child and Adolescent Psychiatry
Magnetic Resonance Imaging
Inhibition
Psychological
Electrophysiology
Treatment Outcome
Attention Deficit Disorder with Hyperactivity
10076 Center for Integrative Human Physiology
Female
Analysis of variance
Psychology
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Zdroj: Neuroscience. 378:89-99
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2016.09.025
Popis: Neurofeedback training (NF) is a promising non-pharmacological treatment for ADHD that has been associated with improvement of attention-deficit/hyperactivity disorder (ADHD)-related symptoms as well as changes in electrophysiological measures. However, the functional localization of neural changes following NF compared to an active control condition, and of successful learning during training (considered to be the critical mechanism for improvement), remains largely unstudied. Children with ADHD (N=16, mean age: 11.81, SD: 1.47) were randomly assigned to either slow cortical potential (SCP, n=8) based NF or biofeedback control training (electromyogram feedback, n=8) and performed a combined Flanker/NoGo task pre- and post-training. Effects of NF, compared to the active control, and of learning in transfer trials (approximating successful transfer to everyday life) were examined with respect to clinical outcome and functional magnetic resonance imaging (fMRI) changes during inhibitory control. After 20 sessions of training, children in the NF group presented reduced ADHD symptoms and increased activation in areas associated with inhibitory control compared to baseline. Subjects who were successful learners (n=9) also showed increased activation in an extensive inhibitory network irrespective of the type of training. Activation increased in an extensive inhibitory network following NF training, and following successful learning through NF and control biofeedback. Although this study was only powered to detect large effects and clearly requires replication in larger samples, the results suggest a crucial role for learning effects in biofeedback trainings.
Databáze: OpenAIRE
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