The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: A randomized placebo controlled trial
| Autor: | Amir Javadi, Maryam Javadi, Parvin Mirmiran, Elham Razmpoosh, Abbas Yousefinejad, Hanieh-Sadat Ejtahed |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Placebo-controlled study 030209 endocrinology & metabolism Type 2 diabetes Placebo Gastroenterology 03 medical and health sciences 0302 clinical medicine Insulin resistance Double-Blind Method Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents 030212 general & internal medicine Glycemic Glycated Hemoglobin medicine.diagnostic_test business.industry Insulin Probiotics General Medicine Middle Aged medicine.disease Prognosis Lipids Hypoglycemia Diabetes Mellitus Type 2 Hyperglycemia Dietary Supplements Female business Lipid profile Biomarkers Follow-Up Studies |
| Zdroj: | Diabetesmetabolic syndrome. 13(1) |
| ISSN: | 1878-0334 |
| Popis: | Aims The role of gut microbiota in the pathogenesis of diabetes is increasing; this study investigates the effect of multi-strain probiotics on fasting plasma glucose (FPG), plasma insulin and lipid profile among patients. Methods This randomized double blind controlled trial was performed among 60 patients; individuals were randomly assigned into 2 groups of 30 participants in order to take either probiotic supplements or placebo for 6 weeks. The probiotic supplement consisted of 7 viable strains Lactobacillus, Bifidobacterium and Streptococcus. Nutrient intakes were estimated using a 3-day and 24 hour-dietary recall at the beginning and end of study. Fasting blood samples were taken before and after intervention to measure the levels of FPG, plasma insulin and lipid profiles. Results Within group comparisons showed significant decrease and increase in the levels of FPG (P = 0.001) and HDL-C (P = 0.002) in probiotic group, respectively. No significant alterations were observed for within and between group comparisons in the levels of insulin, triglycerides, total cholesterol, insulin resistance and anthropometric measurements, including weight, waist circumference and body mass index (all P > 0.05). Conclusions This study showed a significant decrease in FPG level by multi-strain probiotic supplements in within group comparison; though, further studies are needed to confirm results. (IRCT Code: IRCT2013100714925N1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect