Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages

Autor: Sharon K. Sahi, Christina M. Marra, Patrick French, Achyuta V Nori, Sheila A. Lukehart, Lauren C. Tantalo, Mathew A. Beale, Nicholas R. Thomson, Michael Marks
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
General Physics and Astronomy
02 engineering and technology
Drug resistance
Azithromycin
urologic and male genital diseases
Bacterial genetics
Pandemic
Genotype
lcsh:Science
Phylogeny
Genetics
0303 health sciences
education.field_of_study
Molecular Epidemiology
Multidisciplinary
Treponema
integumentary system
Transmission (medicine)
Genomics
021001 nanoscience & nanotechnology
3. Good health
Anti-Bacterial Agents
Phylogenetics
Macrolides
0210 nano-technology
Lineage (genetic)
Science
Population
Epidemiology of syphilis
Biology
General Biochemistry
Genetics and Molecular Biology
Article
03 medical and health sciences
Antibiotic resistance
Species Specificity
Drug Resistance
Bacterial
medicine
Humans
Syphilis
Treponema pallidum
education
Pandemics
030304 developmental biology
Molecular epidemiology
030306 microbiology
General Chemistry
Sequence Analysis
DNA
biology.organism_classification
medicine.disease
030104 developmental biology
lcsh:Q
Bacterial infection
Genome
Bacterial
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
ISSN: 2041-1723
Popis: Syphilis is a sexually transmitted infection caused by Treponema pallidum subspecies pallidum and may lead to severe complications. Recent years have seen striking increases in syphilis in many countries. Previous analyses have suggested one lineage of syphilis, SS14, may have expanded recently, indicating emergence of a single pandemic azithromycin-resistant cluster. Here we use direct sequencing of T. pallidum combined with phylogenomic analyses to show that both SS14- and Nichols-lineages are simultaneously circulating in clinically relevant populations in multiple countries. We correlate the appearance of genotypic macrolide resistance with multiple independently evolved SS14 sub-lineages and show that genotypically resistant and sensitive sub-lineages are spreading contemporaneously. These findings inform our understanding of the current syphilis epidemic by demonstrating how macrolide resistance evolves in Treponema subspecies and provide a warning on broader issues of antimicrobial resistance.
Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum (TPA), and incidence has risen recently in many countries. Here, Beale et al. provide whole-genome TPA sequences from 73 clinical samples and show how antimicrobial resistance emerged independently in circulating lineages.
Databáze: OpenAIRE
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