Function and dysfunction of two-pore channels
| Autor: | Sandip Patel |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Nicotinic acid adenine dinucleotide phosphate
Release channel Endolysosomal membrane SUPERFAMILY Endosomes Cell Biology NADP metabolism Biology Models Biological Biochemistry Cell biology chemistry.chemical_compound chemistry Animals Humans Calcium Calcium Channels Calcium Signaling Lysosomes Molecular Biology Ebola virus infection NADP Ion channel Function (biology) |
| Zdroj: | Science Signaling. 8 |
| ISSN: | 1937-9145 1945-0877 |
| DOI: | 10.1126/scisignal.aab3314 |
| Popis: | Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion channel superfamily. TPCs localize to acidic Ca(2+) stores within the endolysosomal system. Most evidence indicate that TPCs mediate Ca(2+) signals through the Ca(2+)-mobilizing messenger nicotinic acid adenine dinucleotide phosphate (NAADP) to control a range of Ca(2+)-dependent events. Recent studies clarify the mechanism of TPC activation and identify roles for TPCs in disease, highlighting the regulation of endolysosomal membrane traffic by local Ca(2+) fluxes. Chemical targeting of TPCs to maintain endolysosomal "well-being" may be beneficial in disorders as diverse as Parkinson's disease, fatty liver disease, and Ebola virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|