The diagnostic accuracy of mid-regional pro-adrenomedullin for sepsis: a systematic review and meta-analysis
| Autor: | Chunmei Wang, Shuqin Pang, Peijuan Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Incidence (epidemiology) MEDLINE Area under the curve Odds ratio Cochrane Library Prognosis medicine.disease Sepsis Adrenomedullin Anesthesiology and Pain Medicine Area Under Curve Internal medicine Meta-analysis medicine Humans Biomarker (medicine) business Biomarkers |
| Zdroj: | Minerva Anestesiologica. 87 |
| ISSN: | 1827-1596 0375-9393 |
| DOI: | 10.23736/s0375-9393.21.15585-3 |
| Popis: | Introduction The incidence and mortality of sepsis are high, and common biomarkers are not perfect. To identify a biomarker with high specificity and sensitivity for sepsis, we evaluated the current literature on the performance of mid-regional pro-adrenomedullin (MR-proADM) in the diagnosis of sepsis. Evidence acquisition According to appropriate eligibility and exclusion criteria, PubMed, EMBASE, Cochrane Library, China Journal full-text Database, Wanfang Database and Chinese Journal Full Text Database were searched for "mid-regional pro-adrenomedullin," "MR-proADM," "sepsis," "pyemia," "pyohemia," "septicemia," and "blood poisoning." The publication dates considered for the search were from inception until August 31st, 2020. The risk of bias was assessed according to QUADAS-2 criteria. Evidence synthesis Eleven studies involving 2038 cases were included. MR-proADM had high sensitivity and specificity in the diagnosis of sepsis, with values of 0.83 (95% CI: 0.79-0.87) and 0.90 (95% CI: 0.83-0.94), respectively. The odds ratio of a combined diagnosis was 41.35, and the area under the curve (AUC) was 0.91. The best cut-off value for MR-proADM diagnosis of sepsis is 1-1.5 nmol/L. MR-proADM may also have value in distinguishing pathogens and identifying sepsis severity and organ failure. Conclusions MR-proADM is an excellent biomarker for the diagnosis of sepsis with high sensitivity and specificity. The best cut-off value for MR-proADM diagnosis of sepsis is 1-1.5 nmol/L. |
| Databáze: | OpenAIRE |
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