A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris
| Autor: | J. Schlottfeldt, B. C. Gil, T. F. Cestari, T. J. Wilson, M. Kruger, P. H. Salim, Mariana Jobim, Gilberto Schwartsmann, R. Toresan, M. R. Jobim, Luiz Fernando Job Jobim |
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| Rok vydání: | 2008 |
| Předmět: |
Immunology
Killer-cell immunoglobulin-like receptor KIR2DS1 Gene Human leukocyte antigen HLA-C Antigens Biology Biochemistry law.invention Natural killer cell Pathogenesis Gene Frequency Receptors KIR law Psoriasis Genetics medicine Immunology and Allergy Humans Genetic Predisposition to Disease Receptor Polymerase chain reaction Alleles General Medicine medicine.disease Molecular biology medicine.anatomical_structure Brazil |
| Zdroj: | Tissue antigens. 72(4) |
| ISSN: | 1399-0039 |
| Popis: | Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic background remain unclear. Considering that previous studies have suggested an association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase chain reaction (PCR) using sequence-specific oligonucleotides and sequence-specific primers. We did not observe a relevant increase in the frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% of controls. These results suggest that activating KIR2DS1 gene may not confer susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ was observed in these patients. |
| Databáze: | OpenAIRE |
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