Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature
| Autor: | Daniel Martinez Saez, Robson Tetsuo Sasaki, Marcelo Cavenaghi Pereira da Silva, Adriana da Costa Neves |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Histology Cell Separation Tissue Banks Biology Tooth Exfoliation Regenerative medicine Cryopreservation 03 medical and health sciences 0302 clinical medicine Tissue engineering Deciduous teeth medicine Humans Immunologic Factors Tooth Deciduous Stem Cells Mesenchymal stem cell 030206 dentistry Anatomy Cell biology Transplantation 030104 developmental biology medicine.anatomical_structure Stem cell Adult stem cell |
| Zdroj: | Cells, tissues, organs. 202(5-6) |
| ISSN: | 1422-6421 |
| Popis: | Adult stem cells research has been considered the most advanced sort of medical-scientific research, particularly stem cells from human exfoliated deciduous teeth (SHED), which represent an immature stem cell population. The purpose of this review is to describe the current knowledge concerning SHED from full-text scientific publications from 2003 to 2015, available in English language and based on the keyword and/or abbreviations ‘stem cells from human exfoliated deciduous teeth (SHED)', and individually presented as to the properties of SHED, immunomodulatory properties of SHED and stem cell banking. In summary, these cell populations are easily accessible by noninvasive procedures and can be isolated, cultured and expanded in vitro, successfully differentiated in vitro and in vivo into odontoblasts, osteoblasts, chondrocytes, adipocytes and neural cells, and present low immune reactions or rejection following SHED transplantation. Furthermore, SHED are able to remain undifferentiated and stable after long-term cryopreservation. In conclusion, the high proliferative capacity, easy access, multilineage differentiation capacity, noninvasiveness and few ethical concerns make stem cells from human exfoliated deciduous teeth the most valuable source of stem cells for tissue engineering and cell-based regenerative medicine therapies. |
| Databáze: | OpenAIRE |
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