Clinical, clinicopathological and histological changes observed in 14 cats treated with glucocorticoids
| Autor: | K. L. Campbell, Andrew D. Lowe, Anne M. Barger, D. J. Schaeffer, Luke B. Borst |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Lymphocyte Prednisolone Anorexia Urinalysis Cat Diseases Gastroenterology Dexamethasone Leukocyte Count Random Allocation Internal medicine White blood cell medicine Animals Glucocorticoids Serum Albumin CATS General Veterinary Dose-Response Relationship Drug business.industry Albumin General Medicine Eosinophil Immunohistochemistry Blood Cell Count medicine.anatomical_structure Endocrinology Liver Cats Erythrocyte Count medicine.symptom business Blood Chemical Analysis medicine.drug |
| Zdroj: | The Veterinary record. 162(24) |
| ISSN: | 0042-4900 |
| Popis: | Fourteen cats were given immunosuppressive doses of either prednisolone (4.4 mg/kg/day) or dexamethasone (0.55 mg/kg/day) for 56 days. Complete blood counts, serum biochemistry profiles and urinalyses were performed on days 0 and 56, and liver biopsies were taken laparoscopically on day 56, because of evidence of hepatic disease on the serum biochemistry profiles. There were significant increases in the cats' mean white blood cell counts, neutrophil counts and monocyte counts, and significant decreases in their mean lymphocyte counts and eosinophil counts. There were consistent increases in the serum concentrations of albumin, glucose, triglycerides and cholesterol. Glycogen deposition, consistent with a steroid hepatopathy, was present to varying degrees in all the liver biopsies. One of the cats developed adverse clinical signs including anorexia, icterus, pruritus and medial curling of the pinnae, some of which were suspected to be related to the glucocorticoid therapy. |
| Databáze: | OpenAIRE |
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