The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein
| Autor: | Ming Lu, A. D. Ho, Weifang Shen, Zhiyuan Gong |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Sequence analysis
T-cell leukemia Molecular Sequence Data Restriction Mapping Chromosomal translocation Biology Proto-Oncogene Mas General Biochemistry Genetics and Molecular Biology Translocation Genetic Gene product Chromosome Walking Complementary DNA Proto-Oncogenes Humans Leukemia-Lymphoma Adult T-Cell Amino Acid Sequence Molecular Biology Gene Genetics Chromosomes Human Pair 14 General Immunology and Microbiology Base Sequence Chromosomes Human Pair 10 General Neuroscience breakpoint cluster region Genes Homeobox Gene rearrangement DNA Blotting Northern Molecular biology RNA Research Article |
| Zdroj: | The EMBO journal. 10(10) |
| ISSN: | 0261-4189 |
| Popis: | The t(10;14)(q24;q11) chromosomal translocation found in malignant cells of 5-10% of patients with T-cell acute lymphoblastic leukemia (T-ALL) involves the T-cell receptor delta chain gene on chromosome 14 and a breakpoint cluster region on chromosome 10. The candidate proto-oncogene tcl-3, thought to be involved in the pathogenesis of t(10;14) T-ALL, was cloned and found to be elevated in expression in leukemic cells harboring the t(10;14) translocation. Sequence analysis revealed that tcl-3 is a new homeobox-containing gene. Comparison of the tcl-3 cDNA and its 5' genomic sequences with DNA sequences from the t(10;14) translocation breakpoints showed that this gene is structurally altered in four patients with t(10;14)(q24;q11) T-ALL. These findings suggest that homeobox-containing genes that normally act as transcription factors may contribute to T-cell leukemogenesis when abnormally expressed. |
| Databáze: | OpenAIRE |
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