Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone
| Autor: | J. J. L. Sienra-Monge, Hortensia Moreno-Macías, Kay M. Crissman, M X Ruiz-Navarro, Norma Isabel Reyes-Ruiz, Gary E. Hatch, Isabelle Romieu, Matiana Ramirez-Aguilar, B. E. del Rio-Navarro, Ralph Slade, Robert B. Devlin |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment alpha-Tocopherol Immunology Ascorbic Acid medicine.disease_cause Placebo Antioxidants chemistry.chemical_compound Ozone Double-Blind Method medicine Humans Vitamin E Immunology and Allergy Child Asthma Air Pollutants Vitamin C Interleukin-6 business.industry Interleukin-8 Environmental Exposure Original Articles medicine.disease Glutathione Uric Acid Oxidative Stress chemistry Dietary Supplements Uric acid Nasal Lavage Female Nasal Cavity business Oxidative stress |
| Zdroj: | Clinical and Experimental Immunology. 138:317-322 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2004.02606.x |
| Popis: | SUMMARY The inflammatory response to ozone in atopic asthma suggests that soluble mediators of inflammation are released in response to oxidant stress. Antioxidants may alleviate additional oxidative stress associated with photochemical oxidant pollution. This study investigates the impact of antioxidant supplementation on the nasal inflammatory response to ozone exposure in atopic asthmatic children. We conducted a randomized trial using a double-blinded design. Children with asthma (n = 117), residents of Mexico City, were given randomly a daily supplement of vitamins (50 mg/day of vitamin E and 250 mg/day of vitamin C) or placebo. Nasal lavages were performed three times during the 4-month follow-up and analysed for content of interleukin-6 (IL-6), IL-8, uric acid and glutathione (GSx). IL-6 levels in the nasal lavage were increased significantly in the placebo group after ozone exposure while no increase was observed in the supplement group. The difference in response to ozone exposure between the two groups was significant (P = 0·02). Results were similar for IL-8, but with no significant difference between the groups (P = 0·12). GSx decreased significantly in both groups. Uric acid decreased slightly in the placebo group. Our data suggest that vitamin C and E supplementation above the minimum dietary requirement in asthmatic children with a low intake of vitamin E might provide some protection against the nasal acute inflammatory response to ozone. |
| Databáze: | OpenAIRE |
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