B and T cells in the brains of autoimmune mice
| Autor: | Steven A. Hoffman, Andleeb Zameer |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Mice
Inbred MRL lpr Pathology medicine.medical_specialty T-Lymphocytes CD3 Immunology Central nervous system Brain tissue urologic and male genital diseases CD19 Autoimmune Diseases Mice Species Specificity immune system diseases medicine Fluorescence microscope Animals Lupus Erythematosus Systemic Immunology and Allergy skin and connective tissue diseases B-Lymphocytes Systemic lupus erythematosus biology business.industry Autoantibody Brain medicine.disease Antigen binding Mice Inbred C57BL medicine.anatomical_structure Neurology biology.protein Neurology (clinical) business |
| Zdroj: | Journal of Neuroimmunology. 146:133-139 |
| ISSN: | 0165-5728 |
| Popis: | Systemic lupus erythematosus (SLE) is an autoimmune disorder that can involve the central nervous system (CNS). Recently, we reported the presence of autoantibodies bound to the brain tissue of murine models of lupus; MRL/lpr and BXSB. We postulated that the source of these autoantibodies was in part due to in situ production, caused by the entry of B and T cells. Frozen brain sections of MRL/lpr and BXSB at 1 and 4 months of age were stained for CD3 (T cells) and CD19 (B cells) markers using an immunofluorescent antibody binding assay. Confocal fluorescence microscopy showed both CD3 + and CD19 + cells at 4 months of age only in MRL/lpr mice. There were no lymphocytes seen in the other autoimmune model, BXSB. Results suggest a difference in the mechanisms by which autoantibodies access the brain in these two autoimmune models of lupus. |
| Databáze: | OpenAIRE |
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