Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study

Autor: Lars La Cour Poulsen, Olav Sundnes, Torsten Eken, William Ottestad, Camilla Schjalm, Tom Eirik Mollnes, Guttorm Haraldsen, Peter Lundbäck
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Critical Care
Short Report
lcsh:Biochemistry
03 medical and health sciences
Young Adult
0302 clinical medicine
Immune system
Immunity
Internal medicine
Genetics
Coagulopathy
medicine
Humans
Alarmins
Innate
lcsh:QD415-436
Prospective Studies
Prospective cohort study
Molecular Biology
Genetics (clinical)
business.industry
lcsh:RM1-950
VDP::Medisinske Fag: 700::Basale medisinske
odontologiske og veterinærmedisinske fag: 710
Middle Aged
medicine.disease
Interleukin-33
Molecular medicine
Interleukin-1 Receptor-Like 1 Protein
VDP::Medical disciplines: 700::Basic medical
dental and veterinary science disciplines: 710
Interleukin 33
Kinetics
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Hospital admission
Molecular Medicine
Wounds and Injuries
Observational study
Female
business
Biomarkers
030215 immunology
Zdroj: Molecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
Molecular medicine (Cambridge, Mass. Print)
Molecular Medicine
Popis: Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma. Methods Plasma samples were serially collected from 136 trauma patients immediately after hospital admission, 2, 4, 6, and 8 h thereafter, and every morning in the ICU. Levels of IL-33 and its decoy receptor sST2 were measured by immunoassays. Results We observed a rapid and transient surge of IL-33 in a subset of critically injured patients. These patients had more widespread tissue injuries and a greater degree of early coagulopathy. IL-33 half-life (t1/2) was 1.4 h (95% CI 1.2–1.6). sST2 displayed a distinctly different pattern with low initial levels but massive increase at later time points. Conclusions We describe for the first time early high-resolution IL-33 concentration kinetics in individual patients after trauma and correlate systemic IL-33 release to clinical data. These findings provide insight into a potentially important axis of danger signaling in humans.
Databáze: OpenAIRE
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