Supplementary Figure 1 from Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Autor: Bita Esmaeli, Anna Yemelyanova, Victor G. Prieto, Kenna Shaw, Agda Karina Eterovic, Ken Chen, Tae-Boom Kim, Doina Ivan, Courtney W. Hudgens, Mark Routbort, Diana Bell, Bo Peng, Thomas L. Kandl, Oded Sagiv, Jing Ning, Jonathan L. Curry, Michael T. Tetzlaff
Rok vydání: 2023
DOI: 10.1158/1078-0432.22468274
Popis: Supplemental Figure 1. Representative images of nuclear grade. Histopathologic grade was defined according to the nuclear morphology and cytoplasmic evidence of sebaceous differentiation comprising the predominance (>50%) of the tumor cells. (A) High grade tumors exhibited enlarged irregular nuclei with high nuclear:cytoplasmic ratio and only focal evidence of sebaceous differentiation (intracytoplasmic vacuoles indenting the nucleus; H&E, 200x). (B) Intermediate grade tumors exhibited similar enlarged nuclei but with lower nuclear:cytoplasmic ratio and more obvious evidence of sebaceous differentiation (H&E, 200x). (C) Well-differentiated tumors showed only slightly enlarged nuclei and frank evidence of sebaceous differentiation (H&E, 200x).
Databáze: OpenAIRE