Characterization of ternary solid dispersions of Itraconazole in polyethylene glycol 6000/polyvidone-vinylacetate 64 blends
| Autor: | Ann Van Schepdael, Ward D’Autry, Sandrien Janssens, Guy Van den Mooter, Hector Novoa de Armas |
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| Rok vydání: | 2008 |
| Předmět: |
Antifungal Agents
Vinyl Compounds Materials science Chemical Phenomena Itraconazole Chemistry Pharmaceutical Pharmaceutical Science Polyethylene glycol Gas Chromatography-Mass Spectrometry Polyethylene Glycols chemistry.chemical_compound Crystallinity X-Ray Diffraction PEG ratio medicine Organic chemistry Desiccation Dissolution chemistry.chemical_classification Calorimetry Differential Scanning Chemistry Physical Temperature Povidone General Medicine Polymer Solubility chemistry Polymer blend Powders Ternary operation Biotechnology Nuclear chemistry medicine.drug |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 69:1114-1120 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/j.ejpb.2008.02.007 |
| Popis: | The good compatibility between Itraconazole and polyvidone-vinylacetate 64 (PVPVA 64) was pointed out previously. However, the dissolution properties of these systems left room for improvement. Therefore polyethylene glycol 6000 (PEG 6000), known for its solubilizing and wetting properties, was added to the PVPVA 64 matrix. Physicochemical analysis showed that up to 10% of PEG 6000 could be mixed with PVPVA 64. Addition of 10%, 20% or 40% of Itraconazole rendered amorphous solid dispersions consisting of a ternary mixed phase and a PVPVA 64 rich amorphous phase. If the PEG 6000 fraction was elevated up to 25% of the carrier, the PEG 6000 crystallinity degree was around 73 ± 0.6%. Up to 20% of Itraconazole could be molecularly dispersed in the 25/75 w/w polymer blend. An Itraconazole melting peak could be detected for the sample containing 40% of drug. Dissolution experiments showed that no benefit was obtained by adding PEG 6000 to the PVPVA 64 matrix for samples containing up to 20% of Itraconazole. The dissolution of the ternary dispersions with 40% of Itraconazole on the other hand showed improvement compared to binary Itraconazole/PVPVA 64 dispersions. |
| Databáze: | OpenAIRE |
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