Association of interferon T+874A and interleukin 12 p40 promoter CTCTAA/GC polymorphism with the need for respiratory support and perinatal complications in low birthweight neonates
| Autor: | László Derzbach, Tivadar Tulassay, Géza Bokodi, Barna Vásárhelyi, Ilona Bányász |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Genotype Gestational Age Polymorphism Single Nucleotide Interferon-gamma Enterocolitis Necrotizing Risk Factors medicine Humans Interferon gamma Allele Ductus Arteriosus Patent Alleles Bronchopulmonary Dysplasia Retrospective Studies Respiratory Distress Syndrome Newborn Respiratory distress Interleukin-12 Subunit p40 business.industry Infant Newborn Obstetrics and Gynecology Pneumonia General Medicine Odds ratio Infant Low Birth Weight medicine.disease Respiration Artificial Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Necrotizing enterocolitis Immunology Interleukin 12 Regression Analysis Original Article Female Hypotension business medicine.drug |
| Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 92:F25-F29 |
| ISSN: | 1468-2052 1359-2998 |
| DOI: | 10.1136/adc.2005.086421 |
| Popis: | Background: Data support the role of interferon (IFN)γ and interleukin (IL)12 in perinatal complications. IFNγ T +874 A and IL12 p40 promoter CTCTAA/GC polymorphisms may have an effect on cytokine production. Methods: DNA was extracted from dried blood samples of 153 low birthweight (LBW) infants and 172 healthy term infants. IFNγ and IL12 genetic polymorphisms were determined to investigate the association between polymorphisms and ventilation characteristics, bronchopulmonary dysplasia (BPD) and other perinatal disorders. Results: The IFNγ +874 A allele was over-represented in LBW infants. Carriers of the IFNγ +874 T allele required mechanical ventilation and oxygen supplementation for time periods 41% and 35%, respectively, shorter than those required by those not carrying the IFNγ +874 T allele. Stepwise logistic regression analysis showed that carriers of the IFNγ +874 T allele were protected against BPD (odds ratio (OR) 0.35 (95% confidence interval (CI) (0.12 to 0.99))) and patent ductus arteriosus (OR 0.43 (95% CI 0.19 to 0.97)), whereas carriers of the IFNγ +874 A allele were at higher risk of severe hypotension (OR 3.40 (95% CI 1.01 to 11.52)) and respiratory distress syndrome (OR 4.03 (95% CI 1.30 to 12.50)). Carriers of the IL12 GC allele were protected against pneumonia (OR 0.32 (95% CI 0.14 to 0.75)). Carriers of the IL12 CTCTAA allele were at higher risk of developing necrotising enterocolitis (NEC; OR 2.37 (95% CI 1.01 to 5.53)). Conclusions: Carrier state of the IFNγ +874 A allele presents an increased risk for premature birth and lung damage, as well as other perinatal complications. The risks of pneumonia and NEC are higher in heterozygotic carriers of the IL12 CTCTAA/GC polymorphism. Further studies are needed to determine whether these associations are the result of altered cytokine-producing capacity in infants carrying the tested alleles. |
| Databáze: | OpenAIRE |
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