The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
Autor: | Cheng-Hsien Lu, Fu-Cheng Chen, Chia-Te Kung, Chih-Cheng Huang, Yun-Ru Lai, Sheng-Yuan Hsiao, Chih-Min Su |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
hospital mortality
Medicine (General) medicine.medical_specialty Receiver operating characteristic Adult patients business.industry Clinical Biochemistry Stepwise regression medicine.disease Gastroenterology sTREM-1 Article Sepsis sepsis R5-920 Internal medicine medicine outcome Biomarker (medicine) SOFA score Endothelial dysfunction Early phase business |
Zdroj: | Diagnostics Volume 11 Issue 11 Diagnostics, Vol 11, Iss 1979, p 1979 (2021) |
ISSN: | 2075-4418 |
DOI: | 10.3390/diagnostics11111979 |
Popis: | Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis. |
Databáze: | OpenAIRE |
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