Synthesis and cellular effects of cycloterpenals: Cyclohexadienal-based activators of neurite outgrowth
| Autor: | Bennie J. Bench, Lisa M. Pérez, Shane E. Tichy, Coran M. H. Watanabe, Jenna Benson |
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| Rok vydání: | 2008 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Whey protein Magnetic Resonance Spectroscopy Neurite Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests PC12 Cells Biochemistry Aldehyde Chemical synthesis Jurkat Cells Cyclohexenes Drug Discovery Neurites medicine Animals Humans Molecular Biology chemistry.chemical_classification Reaction conditions Aldehydes Organic Chemistry Cell Differentiation In vitro Rats medicine.anatomical_structure chemistry Cell culture Biophysics Molecular Medicine Neuron |
| Zdroj: | Bioorganic & Medicinal Chemistry. 16:7573-7581 |
| ISSN: | 0968-0896 |
| Popis: | An unusual class of diterpenoid natural products, ‘cycloterpenals’ (with a central cyclohexadienal core), that arise in nature by condensation of retinoids and other isoprenes, have been isolated from a variety of organisms including marine sponges as well as from the human eye. A milk whey protein has also demonstrated the formation of a cycloterpenal derived from β-ionylidineacetaldehyde. Here, we generate a synthetic library of these molecules where we detail reaction conditions required to effect cross condensation of α,β-unsaturated aldehydes as opposed to homodimerization. The ability of this class of molecules to activate neurite outgrowth activity is reported. |
| Databáze: | OpenAIRE |
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