Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression
| Autor: | Palomba E, Sergio Crovella, Antonio Amoroso, Gabriella Scarlatti, Laura Vatta, Andrea Spanò, Pier-Angelo Tovo, Michele Boniotto, Silvia Zezlina, Doroti Pirulli |
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| Přispěvatelé: | Boniotto, M, Crovella, Sergio, Pirulli, D, Scarlatti, G, Spano', A, Vatta, L, Zezlina, S, Tovo, Pa, Palomba, E, Amoroso, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Immunology
Human immunodeficiency virus (HIV) HIV Infections Biology HIV-1 infection medicine.disease_cause Mannose-Binding Lectin promoter region Acquired immunodeficiency syndrome (AIDS) Pregnancy Risk Factors Genetics medicine Humans MBL2 Mannose-binding protein AIDS progression Pregnancy Complications Infectious Promoter Regions Genetic Genetics (clinical) DNA Primers Mannan-binding lectin Acquired Immunodeficiency Syndrome Polymorphism Genetic Base Sequence Transmission (medicine) Infant Newborn virus diseases Promoter medicine.disease Virology Infectious Disease Transmission Vertical Mannose-Binding Lectins Case-Control Studies HIV-1 Female Carrier Proteins |
| Zdroj: | Scopus-Elsevier |
| Popis: | We investigated the polymorphisms of the promoter region of the MBL2 gene, which codifies for the Mannose-binding protein (MBP). The study population included 90 children with vertically acquired HIV-infection, further divided on the basis of the disease rate, 27 HIV exposed-uninfected children, and 74 healthy control subjects matched for ethnic origin to evaluate the MBP involvement in the risk of HIV-1 infection and to assess the role of the MBP promoter in AIDS progression. A region of 380 bp in the promoter of the MBL2 gene was analysed by PCR and direct sequencing of both DNA strands. We found that the polymorphism at position -550 influences the risk of HIV-infection and AIDS progression. Also a 6 bp deletion at position -328 was correlated with HIV-1 infection. This study indicates that the promoter of the MBL2 gene influences vertical transmission of HIV and the course of perinatal infection. |
| Databáze: | OpenAIRE |
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