Correlation of chromosomal aberrations in a myeloma cell line with tumorigenicity in nude mice
| Autor: | Michael Schaadt, K. P. Hellriegel, C. Fonatsch, M. Günzel, Volker Diehl, Hartmut Kirchner |
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| Rok vydání: | 1981 |
| Předmět: |
Chromosome Aberrations
medicine.medical_specialty Hematology Mice Nude Chromosome Karyotype General Medicine Biology Malignancy medicine.disease Molecular biology In vitro Cell Line Transplantation Mice Cell culture Karyotyping Internal medicine medicine Animals Humans Multiple Myeloma Chromosomes Human 13-15 Multiple myeloma |
| Zdroj: | Blut. 43:93-97 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf00320467 |
| Popis: | A human myeloma cell line (L 363) exhibiting several markers of malignancy including a 14q + chromosome marker was not tumorigenic in nude mice. Long-term cultivation in vitro resulted in new subclones with slight, well-defined chromosomal differences to the original line. Certain subclones turned out to have a growth advantage in vitro and became tumorigenic after transplantation in nude mice. A strong correlation between changes in the chromosome I constellation resulting in the threefold dose of long arm-material and the increased proliferative potential in both experimental systems was found. |
| Databáze: | OpenAIRE |
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