Clinical characteristics and leakage of functioning blebs after trabeculectomy with mitomycin-C in primary glaucoma patients
| Autor: | Yasuyuki Suzuki, Chao-Yu Hu, Shiroaki Shirato, Makoto Araie, Goji Tomita, Sumiyoshi Tanaka, Hiroshi Matsuo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure Adolescent genetic structures Mitomycin Eye disease medicine.medical_treatment Glaucoma Trabeculectomy Aqueous Humor Tonometry Ocular Postoperative Complications Ophthalmology medicine Humans Prospective Studies Bleb (cell biology) Prospective cohort study Intraocular Pressure Aged Aged 80 and over Antibiotics Antineoplastic business.industry Middle Aged medicine.disease Combined Modality Therapy eye diseases Suction blister Surgery Sclera surgical procedures operative medicine.anatomical_structure Female sense organs Glaucoma Angle-Closure business Glaucoma Open-Angle |
| Zdroj: | Ophthalmology. 110:345-352 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(02)01739-6 |
| Popis: | To describe the clinical characteristics of functioning blebs in Japanese glaucoma patients after primary trabeculectomy with adjunctive mitomycin-C (MMC) and to correlate their associations with postoperative bleb leakage.A prospective, observational case series.One hundred sixty-two glaucoma patients who had undergone primary trabeculectomy with MMC at the University of Tokyo Hospital at least 3 months before were examined between December 1997 and February 1998.A predesigned data form was completed at each visit. Ophthalmologic examinations included Goldmann applanation tonometry, slit-lamp examination, and Seidel tests with and without digital ocular pressure (DOP).Properties of the functioning bleb, including bleb appearance, thickness of bleb wall, dimensions of bleb and avascular area, and leakage status with and without DOP.Of 162 Japanese patients, 162 eyes with functioning blebs were included. There were no differences in bleb characteristics among the different types of primary glaucoma. With a long postoperative duration, blebs tended to be thinner (P = 0.024). With DOP, the leaking rate increased from 3.1% to 5.6%, and the oozing rate increased from 11.1% to 35.8% (P0.001). Logistic regression analysis indicated that the larger the avascular area, the more likely the bleb leaked without DOP (P = 0.016). When DOP was applied, leakage was more likely to occur in the blebs with a long postoperative duration (P = 0.002) or with a large avascular area (P0.001).The clinical characteristics of filtering blebs were similar in Japanese patients with different types of primary glaucoma. Blebs with a large avascular area were associated with a higher risk of bleb leakage. Attention to the increased chance of leakage induced by DOP is important, especially for blebs with a long postoperative duration. Ophthalmologists should be aware of late bleb-related complications in addition to bleb function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|