Prognostic Significance of Immuno-Proteosome Subunit Expression in Patients with Renal-Cell Carcinoma: A Preliminary Study
| Autor: | Kazuya Kanda, Kinya Yokota, Hiro-omi Kanayama, Susumu Kagawa, Yoshihide Murakami |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Proteasome Endopeptidase Complex Urology Protein subunit Statistics as Topic Antigen presentation Gene Expression Genes MHC Class I Biology Major histocompatibility complex Viral Matrix Proteins Multienzyme Complexes Renal cell carcinoma Gene expression MHC class I Carcinoma medicine Humans Carcinoma Renal Cell Survival rate Antigen Presentation Histocompatibility Antigens Class I Proteins Prognosis medicine.disease Kidney Neoplasms Survival Rate Cysteine Endopeptidases Protein Subunits Immunology biology.protein Cancer research Female |
| Zdroj: | Molecular Urology. 5:113-119 |
| ISSN: | 1091-5362 |
| Popis: | Our purpose was to elucidate the clinical roles of the "immuno-proteosome," which is involved in the accelerated pathway of the major histocompatibility complex (MHC) class I-restricted antigen presentation system, in renal cell carcinoma (RCC). The relative expression of six proteosome subunits (existing subunits X, Y, and Z and immunoproteosome subunits LMP7, LMP2, and MECL1) in 54 RCCs was investigated using RT-PCR analysis and was compared with clinicopathological measures, including patient outcome. Expression of the LMP7 and LMP2 genes was significantly low in high-grade tumors, and that of the LMP7 and MECL1 genes was significantly low in high-stage tumors. Low levels of LMP7, LMP2, and MECL1 expression were strongly associated with shortened survival (LMP7: P = 0.0002, LMP2: P < 0.0001, MECL1: P < 0.0047). The levels of subunits X, Y, and Z had no significant correlation with those measures. These findings suggest that RCCs with low level of immuno-proteosome subunit expression have a disorder in their antigen-presentation system. As a consequence, they may escape from immune surveillance and worsen patient outcome. |
| Databáze: | OpenAIRE |
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