Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial
| Autor: | João Pedro Ribeiro Afonso, André Luis Lacerda Bachi, Luis Vicente Franco de Oliveira, Manoel Carneiro Oliveira Junior, Adriano Luís Fonseca, Miriã Cândida Oliveira, Marcos Mota da Silva, Rodolfo de Paula Vieira, Vera Lúcia dos Santos Alves, Wilson José Sena Pedro, Alan Robson Trigueiro de Sousa, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Anderson Soares da Silva, Eduardo Araujo Perez, Giuseppe Insalaco, Wilson Rodrigues de Freitas Junior, Maria Eduarda Moreira Lino |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Bariatric Surgery Adipokine chemistry.chemical_compound Adipokines Weight loss Weight Loss medicine Humans Obesity Inflammation Nutrition and Dietetics medicine.diagnostic_test Cholesterol business.industry medicine.disease Pathophysiology Obesity Morbid Surgery Clinical trial chemistry Female Resistin medicine.symptom Severe obesity business Lipid profile |
| Zdroj: | Obesity surgery (2021). doi:10.1007/s11695-021-05702-5 info:cnr-pdr/source/autori:Alan Robson Trigueiro de Sousa; Wilson Rodrigues Freitas Junior; Eduardo Araujo Perez; Elias Jirjoss Ilias; Anderson Soares Silva; Vera Lucia Santos Alves; João Pedro Ribeiro Afonso; Miriã Cândida Oliveira; Adriano Luís Fonseca; Marcos Mota da Silva; Maria Eduarda Moreira Lino; Manoel Carneiro Oliveira Junior; Rodolfo Paula Vieira; Wilson José Sena Pedro; André Luis Lacerda Bachi;· Giuseppe Insalaco; Carlos Alberto Malheiros; Luis Vicente Franco Oliveira/titolo:Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial/doi:10.1007%2Fs11695-021-05702-5/rivista:Obesity surgery/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | Introduction/Purpose Obesity increases significantly every year worldwide. Since 1980, the prevalence of individuals with obesity has practically doubled. Obesity plays an important role in the pathophysiology of diseases that arise from a complex interaction of nutritional, genetic, and metabolic factors, characterizing a chronic inflammatory state. This study aimed to verify the systemic inflammatory response through the analysis of IGF-1, IL-23, and resistin levels and the lipid profile in severely obese women undergoing surgery for obesity and weight-related diseases. Materials and Methods This randomized controlled clinical trial includes female patients clinically diagnosed with severe obesity with an indication for bariatric surgery. Results In the initial evaluation, no significant difference was observed between the control (CG) and bariatric surgery (BSG) groups. The weight, BMI, systolic and diastolic blood pressures, total cholesterol, LDL, HDL, total non-HDL cholesterol, and glucose in BSG patients showed a significant change after surgery. Pre- and post-surgery levels of resistin, IGF-1, and IL-23 showed a significant difference in the BSG group, but only IL-23 was changed after 6 months in the CG. Conclusion The results of this study confirmed that weight loss induced by surgery for obesity and weight-related diseases improved the lipid profile and reduced the chronic inflammatory status in women with severe obesity. |
| Databáze: | OpenAIRE |
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