Calcium-associated mechanisms in gut pacemaker activity
| Autor: | Miyako Takaki, Shinsuke Nakayama, Hong Nian Liu, Kazunori Goto, Shunichi Kajioka |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
voltage-gated Ca2+channels transient receptor potential (TRP) homologues Reviews interstitial cells of Cajal chemistry.chemical_element Ca2+-activated Cl−channels Calcium Biology smooth muscle symbols.namesake Biological Clocks Chloride Channels c-Kit Internal medicine medicine Animals Humans calcium oscillations non-selective cation channels inositol trisphosphate receptors Calcium Signaling Calcium signaling Gastrointestinal tract Voltage-dependent calcium channel Ryanodine receptor Cell Biology Interstitial cell of Cajal Gastrointestinal Tract Endocrinology chemistry ryanodine receptors symbols Chloride channel Molecular Medicine Calcium Channels Intracellular |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-1838 |
| DOI: | 10.1111/j.1582-4934.2007.00107.x |
| Popis: | A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs. |
| Databáze: | OpenAIRE |
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