Adenovirus Infection in Children With Acute Myeloid Leukemia
| Autor: | Samuele Renzi, Salah Ali, Carol Portwine, David Mitchell, David Dix, Victor Lewis, Victoria Price, Michelle Science, Lillian Sung |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Canada Myeloid Adolescent 030106 microbiology Population Adenoviridae Adenovirus Infections Human Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors hemic and lymphatic diseases Ribavirin medicine Humans Adenovirus infection Child education Retrospective Studies education.field_of_study biology business.industry Immunoglobulins Intravenous Infant Myeloid leukemia Retrospective cohort study Prognosis medicine.disease Leukemia Myeloid Acute Leukemia Infectious Diseases medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Immunology biology.protein Female Antibody business Cohort study |
| Zdroj: | Pediatric Infectious Disease Journal. 37:135-137 |
| ISSN: | 0891-3668 |
| Popis: | Children with acute myeloid leukemia (AML) are at high risk of life-threatening bacterial and fungal infection. However, little is known about the prevalence or severity of adenovirus infection in this population. Objective was to describe the characteristics, treatments and outcomes of adenovirus infection in children with newly diagnosed AML.We performed a retrospective chart review based upon 2 multicenter cohort studies that focused on identifying risk factors for infection in children with AML. Inclusion criteria were patients with de novo AML who were ≤18 years of age at diagnosis with a clinical specimen positive for adenovirus.Among the 235 patients with AML, 12 (5.1%) had positive adenovirus testing. The most common site of isolation was stool (n = 11, 91.6 %), and the most frequent symptom was diarrhea (n = 11, 91.6 %). Two patients received specific treatment for adenovirus, namely intravenous immunoglobulin only in 1 patient and both intravenous immunoglobulin and inhaled ribavirin in a second patient. In 11 patients, adenovirus resolved uneventfully without recurrence, including 10 that received no adenovirus-specific therapy. However, 1 patient developed sepsis syndrome in the setting of disseminated adenoviral infection and died from multiorgan failure.In children with AML, adenovirus infection was rare and typically not associated with severe disease, even without specific treatment. However, disseminated and fatal disease can occur in this population. Further investigations are needed to identify pediatric AML patients at particular risk for severe adenovirus infection and to determine optimal treatment approaches in these patients. |
| Databáze: | OpenAIRE |
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