Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

Autor:	Moriah R. Arnold, Marie-France Langelier, Jessica Gartrell, Ilsa T. Kirby, Daniel J. Sanderson, Daniel S. Bejan, Justina Šileikytė, Sunil K. Sundalam, Shanthi Nagarajan, Parthiban Marimuthu, Anna K. Duell, Anang A. Shelat, John M. Pascal, Michael S. Cohen
Rok vydání:	2022
Předmět:	Pharmacology Clinical Biochemistry Drug Discovery Molecular Medicine Molecular Biology Biochemistry
Zdroj:	Cell Chemical Biology. 29:1694-1708.e10
ISSN:	2451-9456
DOI:	10.1016/j.chembiol.2022.11.006
Popis:	Allosteric coupling between the DNA binding site to the NAD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b0db6a51f0b0f60c2a866c5ae67093 https://doi.org/10.1016/j.chembiol.2022.11.006 Zobrazit plný text záznamu