THE EFFECT OF CORTISONE ON THE IODINE ACCUMULATING FUNCTION OF THE THYROID GLAND IN EUTHYROID SUBJECTS*
| Autor: | Rosalyn S. Yalow, Solomon A. Berson |
|---|---|
| Rok vydání: | 1952 |
| Předmět: |
endocrine system
medicine.medical_specialty Wolff–Chaikoff effect Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Thyroid Gland Biochemistry Cushing syndrome Endocrinology Internal medicine medicine Adrenal insufficiency Humans Euthyroid business.industry Adrenal cortex Biochemistry (medical) Thyroid medicine.disease Cortisone medicine.anatomical_structure business Iodine medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 12:407-422 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-12-4-407 |
| Popis: | THIRTY years ago Marine and Baumann (1) noted that adrenal insufficiency in rabbits led to an increase in heat production and respiratory exchange and to the appearance of a symptom complex resembling exophthalmic goiter. Marine (2) subsequently reviewed the evidence pointing to the importance of a primary adreno-gonadal insufficiency as a possible fundamental cause of Graves' disease. The occurrence of Graves' disease following roentgen ray damage to the adrenal cortex in 2 cases reported by Oppenheimer (3) provided a direct clinical example in support of this concept. The pathologic changes observed in patients who have died of thyrotoxicosis—enlargement of the thymus, diffuse lymphoid hyperplasia and small adrenal cortices—have been cited as evidence suggestive of adrenal cortical insufficiency (2). The endocrine antithesis to the hyperthyroid-hypoadrenocortical state is well demonstrated by the frequent occurrence of an atrophied thyroid gland in Cushing's syndrome (4). The high concentration of serum... |
| Databáze: | OpenAIRE |
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