Impact of perinatal exposure to high-fat diet and stress on responses to nutritional challenges, food-motivated behaviour and mesolimbic dopamine function
Autor: | Marion Rincel, Amandine Lépinay, Hortense Fanet, Muriel Darnaudéry, Stéphanie Caillé, Sylvie Vancassel, Martine Cador, Sophie Layé, L Alonso, L Xia, Marina Romaní-Pérez |
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Přispěvatelé: | Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS) |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male Stress prénatal Maternal Nutritional Physiological Phenomena Endocrinology Diabetes and Metabolism Dopamine synergy Medicine (miscellaneous) Régime maternel human health 0302 clinical medicine Pregnancy 2. Zero hunger Maternal deprivation Synergisme Nutrition and Dietetics Perinatal Exposure Maternal Deprivation digestive oral and skin physiology Santé humaine Prenatal Exposure Delayed Effects Female medicine.symptom Signal Transduction medicine.medical_specialty Mesolimbic dopamine Diet High-Fat 03 medical and health sciences Internal medicine medicine Animals Obésité Obesity Rats Wistar Dopamine metabolism business.industry High fat diet Feeding Behavior medicine.disease Rats Disease Models Animal 030104 developmental biology Endocrinology business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Weight gain 030217 neurology & neurosurgery Stress Psychological |
Zdroj: | International Journal of Obesity International Journal of Obesity, Nature Publishing Group, 2017, 41 (4), pp.502-509. ⟨10.1038/ijo.2016.236⟩ International Journal of Obesity, 2017, 41 (4), pp.502-509. ⟨10.1038/ijo.2016.236⟩ |
ISSN: | 1476-5497 0307-0565 |
Popis: | Background/Objectives: Energy-dense food exposure and stress during development have been suggested to contribute to obesity and metabolic disorders later in life. Although these factors are frequently associated, the effects of their combination have not yet been investigated. In this study, using an animal model, we examined the long-term impact of maternal high-fat diet (HFD) and early-life stress (ELS) on energy homoeostasis control and food motivation.Methods: Body weight growth under HFD, adipose tissue, body weight control in response to fasting and refeeding, food-motivated behaviour and mesolimbic dopamine function were examined in adult male offspring exposed to maternal HFD (during gestation and lactation) and/or ELS (maternal separation 3 h per day from postnatal day 2 to 14).Results: Maternal HFD or ELS alone had no significant effect on offspring body weight; however, the combination of these factors exacerbated body weight gain when animals were exposed to HFD after weaning. There are no other significant combinatory effects of these perinatal events. In contrast, independently of the maternal diet, ELS disrupted body weight control during a fasting–refeeding procedure, increased adipose tissue mass and altered lipid metabolism. Finally, maternal HFD and ELS both resulted in exacerbated food-motivated behaviour and blunted dopamine release in the nucleus accumbens during palatable food consumption.Conclusions: We report a synergistic effect of perinatal HFD exposure and stress on the susceptibility to gain weight under HFD. However, ELS has a stronger impact than maternal HFD exposure on energy homoeostasis and food motivation in adult offspring. Altogether, our results suggest a programming effect of stress and nutrition supporting the hypothesis of the developmental origin of health and disease. |
Databáze: | OpenAIRE |
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