Impact of perinatal exposure to high-fat diet and stress on responses to nutritional challenges, food-motivated behaviour and mesolimbic dopamine function

Autor: Marion Rincel, Amandine Lépinay, Hortense Fanet, Muriel Darnaudéry, Stéphanie Caillé, Sylvie Vancassel, Martine Cador, Sophie Layé, L Alonso, L Xia, Marina Romaní-Pérez
Přispěvatelé: Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Stress prénatal
Maternal Nutritional Physiological Phenomena
Endocrinology
Diabetes and Metabolism
Dopamine
synergy
Medicine (miscellaneous)
Régime maternel
human health
0302 clinical medicine
Pregnancy
2. Zero hunger
Maternal deprivation
Synergisme
Nutrition and Dietetics
Perinatal Exposure
Maternal Deprivation
digestive
oral
and skin physiology
Santé humaine
Prenatal Exposure Delayed Effects
Female
medicine.symptom
Signal Transduction
medicine.medical_specialty
Mesolimbic dopamine
Diet
High-Fat
03 medical and health sciences
Internal medicine
medicine
Animals
Obésité
Obesity
Rats
Wistar
Dopamine metabolism
business.industry
High fat diet
Feeding Behavior
medicine.disease
Rats
Disease Models
Animal
030104 developmental biology
Endocrinology
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Weight gain
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: International Journal of Obesity
International Journal of Obesity, Nature Publishing Group, 2017, 41 (4), pp.502-509. ⟨10.1038/ijo.2016.236⟩
International Journal of Obesity, 2017, 41 (4), pp.502-509. ⟨10.1038/ijo.2016.236⟩
ISSN: 1476-5497
0307-0565
Popis: Background/Objectives: Energy-dense food exposure and stress during development have been suggested to contribute to obesity and metabolic disorders later in life. Although these factors are frequently associated, the effects of their combination have not yet been investigated. In this study, using an animal model, we examined the long-term impact of maternal high-fat diet (HFD) and early-life stress (ELS) on energy homoeostasis control and food motivation.Methods: Body weight growth under HFD, adipose tissue, body weight control in response to fasting and refeeding, food-motivated behaviour and mesolimbic dopamine function were examined in adult male offspring exposed to maternal HFD (during gestation and lactation) and/or ELS (maternal separation 3 h per day from postnatal day 2 to 14).Results: Maternal HFD or ELS alone had no significant effect on offspring body weight; however, the combination of these factors exacerbated body weight gain when animals were exposed to HFD after weaning. There are no other significant combinatory effects of these perinatal events. In contrast, independently of the maternal diet, ELS disrupted body weight control during a fasting–refeeding procedure, increased adipose tissue mass and altered lipid metabolism. Finally, maternal HFD and ELS both resulted in exacerbated food-motivated behaviour and blunted dopamine release in the nucleus accumbens during palatable food consumption.Conclusions: We report a synergistic effect of perinatal HFD exposure and stress on the susceptibility to gain weight under HFD. However, ELS has a stronger impact than maternal HFD exposure on energy homoeostasis and food motivation in adult offspring. Altogether, our results suggest a programming effect of stress and nutrition supporting the hypothesis of the developmental origin of health and disease.
Databáze: OpenAIRE
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