| Autor: |
Edward J. Carr, James Dooley, Michael Meyer-Hermann, Michelle A. Linterman, Danika L. Hill, Alice E Denton, Philippe Robert, Adrian Liston, Alyssa Silva-Cayetano |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
bioRxiv |
| Popis: |
Summary The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed in part to a reduction in the germinal center response, which generates long-lived antibody-secreting cells that provide protection against (re)infection. Despite intensive investigation into the effect of age on the lymphoid compartment, how age impacts on the stromal cell compartment is not understood. Herein we demonstrate that ageing reduces the capacity of germinal center-associated stromal cells to respond to vaccination. Heterochronic parabiosis demonstrates that the age of the microenvironment dictates the size of the germinal center response, irrespective of the age of immune cells. This study reveals that age-associated defects in stromal cells are a significant barrier to efficacious vaccine responses in older individuals. Highlights – The stromal cell response to immunization is impaired in aged mice – Immunization induces remodeling of marginal reticular cells – Age impairs MRC activation and proliferation – Heterochronic parabiosis identifies that age-associated defects in the microenvironment underpin poor GC responses |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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