Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
| Autor: | Yuxian Zhang, Weijuan Su, Shunhua Wang, Liying Wang, Ting Wu, Xuejun Li, Mingzhu Lin, Qiuhui Jiang |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
autoimmune polyglandular syndrome type 3 endocrine system diseases Graves' disease Immunology Case Report Disease Hypothalamic disease isolated gonadotropin-releasing hormone deficiency Autoimmune Process GnRH stimulation test medicine Immunology and Allergy Endocrine system Type 1 diabetes business.industry Thyroid RC581-607 medicine.disease secondary amenorrhea medicine.anatomical_structure Immunologic diseases. Allergy Graves’ disease business type 1 diabetes mellitus hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | APS (autoimmune polyglandular syndrome) is defined as the coexistence of at least two kinds of endocrine autoimmune diseases. APS type 3 comprises autoimmune thyroid diseases and other autoimmune diseases but does not involve autoimmune Addison’s disease. So far, APS-3 combined with isolated gonadotropin-releasing hormone (GnRH) reduction caused by the suspected autoimmune hypothalamic disease has not been reported. We recently received a 43-year-old woman with a one-year history of Graves’ disease (GD) and a four-month history of type 1 diabetes presented with hyperthyroidism and hyperglycemia. After the GnRH stimulation test, she was diagnosed with secondary amenorrhea attributed to suspected autoimmune Hypothalamitis and APS type 3 associated with Graves’ disease and Latent Autoimmune Diabetes (LADA). According to this case, the hypothalamus cannot be spared from the general autoimmune process. It is recommended to carry out the GnRH stimulation test when encountering APS patients combined with secondary amenorrhea. |
| Databáze: | OpenAIRE |
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