| Autor: |
Karaahmet, Berke, Le, Linh, Mendes, Monique S., Majewska, Ania K., O’Banion, M. Kerry |
| Rok vydání: |
2022 |
| DOI: |
10.6084/m9.figshare.20224744 |
| Popis: |
Additional file 4: Figure S4. Repopulation of microglia does not alter behavior in 21-month-old male 3xTg mice. 21-month-old 3xTg mice were treated with control or PLX5622 chow for 14 days and then returned to control chow for the remainder of the experiment. After 22 days on control chow, behavioral assessments were conducted using Open Field, Novel Object Recognition, Lashley III maze, and Fear Conditioning (A). No differences were measured across groups in time spent in the open arena of the open field test (B) or the recognition index in the Novel Object Recognition task (C). To assess spatial memory in a stress-free environment the Lashley Maze was used as depicted. Mice were trained over 8 days to reach the pseudo-home cage from the start box in 10-min sessions each day. No change in the number of zone entries was observed between groups (D). No changes between the groups in the time spent freezing to the conditioned context (E) or the tone stimulus (F) were noted. Student’s t-test. Data are presented as mean ± SEM, n = 14–16. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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